Tricyclic Antidepressants (TCAs)

The tricyclic antidepressants share a common three-ring or "tricyclic" chemical structure, but they are not identical. The composition of the rings and the chemicals attached to the rings are what make them different. Since their general chemical properties are similar, their mode of action and their side effects are somewhat alike.

Two older tricyclic antidepressants (imipramine [Tofranil] and amitriptyline [Elavil]) have shown benefit in research trials and have been used in the treatment of PTSD. Tricyclic antidepressants are not preferred treatments, primarily because of their more frequent and troublesome side effects.

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